A recent study suggests that people who come off blockbuster slimming jabs like semaglutide or tirzepatide may regain shed pounds far faster than those who halt conventional diet and exercise plans.
Findings released in a prominent health publication points out that while obese individuals often shed about a fifth of their total mass while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month once they quit.
"Users purchasing these drugs should be aware of the danger of fast rebound weight gain when the therapy ends," stated expert Dr. Susan Jebb.
Such speed of recovery suggests a reversion to original weight in about 18 months.
Analyzing Approaches
The research, which reviewed 37 of studies involving thousands of patients, compared the outcomes of these new drugs with older methods.
Researchers note that individuals who lose weight through diet and exercise typically see a slower weight regain—approximately 100 grams monthly—post-intervention.
Explaining the Fast Rebound
Nutrition scientists propose the mode of action of the drugs explains the heightened rebound.
The injections copy a body's own chemical called GLP-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous GLP-1, and may also lessen sensitivity to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Stopping of this medication means appetite is no longer kept in check, making overeating far more likely."
An Ongoing Issue?
Medical guidelines advise the jabs for people with weight-linked medical conditions, accompanied by prescribed diet and exercise modifications.
Professionals argue that, considering the high risk of weight regain, the therapy should be considered ongoing.
This perspective is reinforced by pharmaceutical companies, who note that the findings "emphasize the persistent nature of excess weight," akin to managing conditions like diabetes.
Patient Testimonies
People who have come off the jabs explain a intense return of cravings.
"I experienced a switch that goes on and I was suddenly starving," described one woman.
The struggle is worsened if patients have not adopted lasting lifestyle or habit modifications during therapy.
Significant Use
Recent estimates suggest that millions of adults in the UK have tried weight-loss jabs in the last 12 months, with desire continuing to grow.
- Adoption is more common among females compared to males.
- The 40s and 50s age group shows the highest level of interest.
- A large proportion access the medications through private healthcare rather than the NHS.
In conclusion, experts stress that while the jabs are effective tools for weight loss, they are not a magic fix and lasting health benefits relies on integrated behavioural support.
